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1994-10-25
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Document 2966
DOCN M94A2966
TI Oral lesions in patients with HIV infection enrolled in CPCRA trials.
The Terry Beirn CPCRA. Community Programs for Clinical Research on AIDS.
DT 9412
AU Torres R; Tobin J; Vaughn A; Podhurst L; Bolden B; Raschella N; St.
Vincent's Hospital, NYC.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):184 (abstract no. PB0165). Unique
Identifier : AIDSLINE ICA10/94369609
AB OBJECTIVE: Oral candidiasis (OC) and hairy leukoplakia (HL) are oral
lesions which have been shown to be markers of HIV disease progression.
Using the Community Programs for Clinical Research on AIDS (CPCRA)
observational and clinical trials database, this study evaluates the
incidence and prevalence or these oral lesions and of esophageal
candidiasis (EC) in a large sample of HIV-infected patients from
community-based settings, in relationship to gender, race and CD4 count.
METHODS: Using a sample of 4226 CPCRA participants followed for a median
time period of 14 months, CD4 specific event rates (per 100 person years
of risk) were calculated and proportional hazard regression analyses
were performed separately for those with and without oral lesions at
baseline. RESULTS: The incidence per 100 person-years of OC, EC and HL
increased with declining CD4 counts. Rates for CD4 < 50, EC = 11.8, OC =
56.5, HL = 8.3. For CD4 50-99, EC = 9.7, OC = 52.1, HL = 7.7. For CD4
100-199, EC = 4.9, OC = 33.1 and HL = 7.0. For CD4 200+, EC = 1.9, OC =
16.3 and HL = 3.8. The incidence of OC is substantially higher than EC
and HL. During follow-up, 247 patients developed EC, 1208 developed OC
and 223 developed HL. Rates of OC and HL were similar among racial
groups, while the rate of HL was significantly higher for males than for
females (CD4 adjusted relative risk = 0.47) p < 0.05. CONCLUSION: EC, OC
and HL occur with increasing frequency as the CD4 count declines. The
rate of HL was significantly higher for males than for females.
DE AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/IMMUNOLOGY
Candidiasis, Oral/*EPIDEMIOLOGY/IMMUNOLOGY Cross-Sectional Studies
Esophagitis/*EPIDEMIOLOGY/IMMUNOLOGY Human HIV
Infections/*EPIDEMIOLOGY/IMMUNOLOGY Incidence Leukocyte Count
Leukoplakia, Hairy/*EPIDEMIOLOGY/IMMUNOLOGY New York/EPIDEMIOLOGY
Proportional Hazards Models Regression Analysis Risk Factors T4
Lymphocytes/IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).